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OBJECTIVE:To explore the role of clinical pharmacists in perioperative pharmaceutical care for patients with low rectal cancer(LRC). METHODS:Clinical pharmacists participated in the perioperative drug therapy and pharmaceutical care for a LRC patient. They assisted physicians to develop pharmaceutical care from aspects of medication objective,individual medication, evaluation of medication rationality. RESULTS:Clinical pharmacists provided medication education for patients,bowel preparation and preanesthetic medication before surgery and offered drug therapy monitoring of fluid replacement,nutritional support,analge-sia, expectorcont, hemostasis, anti-infective agents and antitumor agents. The patient was discharged successfully. CONCLU-SIONS:Clinical pharmacists participate in perioperative pharmaceutical care and adjust medication timely according to disease con-dition to reduce postoperative complications and ADR,guarantee the safety of drug use and promote rational drug use during periop-erative period.
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OBJECTIVE:To investigate the improvement effect of Prostatitis capsule on chronic non-bacterial prostatitis(CNP) model rats. METHODS:60 rats were randomly divided into sham operation group (distilled water),model group (distilled wa-ter),Pule'an tablet group(positive control,2 g/kg)and Prostatitis capsule high-dose,medium-dose,low-dose groups(16,8,4 g/kg). Except for sham operation group,other 5 groups were injected Xiaozhiling injection 0.2 mL to reduce CNP model. After 7 d of modeling,they received related medicines,ig,once a day,for 45 d. After 24 h of last administration,prostate lesions were ob-served by eyes and wet quality was weighed. White blood cell(WBC)count and lecithin body(SPL)count were conducted under microscope,and prostate tissue slices were pathologically observed. RESULTS:Compared with sham operation group,prostate showed gray nodules,adhesion in glands and surrounding tissue;wet quality of prostate and WBC,SPL count in prostate tissue were significantly increased(P<0.01);under microscope,there were significant congestion,edema and a variety of inflammatory cell infiltration in prostate interstitial. Compared with model group,gray nodules in prostate in Pule'an tablet group and Prostatitis capsule group were reduced,as well as adhesion degree in prostate and surrounding tissue;wet quality of prostate and WBC,SPL count in prostate tissue were significantly decreased(P<0.01);pathological changes had improved to varying degrees under micro-scope,especially the changes in Prostatitis capsule high-dose group,and prostate tissue only showed mild congestion,edema and little inflammatory cell infiltration. CONCLUSIONS:Prostatitis capsule has a certain improvement effect on CNP model rats.
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OBJECTIVE:To establish the quality standard for Prostatitis capsules. METHODS:TLC method was performed to qualitatively identify Pseudostellaria heterophylla,Acortw tatarinowii,Sargentodoxa cuneata,Rubia cordifolia and Vaccaria segeta-lis in the preparation. HPLC method was adopted to determine the content of leonurine in the preparation. The determination was performed on Agilent Eclipse XDB-C18 column with mobile phase consisted of methanol-0.025 mol/L potassium dihydrogen phos-phate(pH adjusted to 2.5)(24 : 76,V/V)with phosphoric acidat the flow rate of 1.0 mL/min. The detection wavelength was set at 277 nm,and column temperature was 30 ℃. The sample size was 10 μL. RESULTS:The TLC spots of P. heterophylla,A. tatari-nowii,S. cuneate,R. cordifolia,and V. segetalis were clear and well-separated without interference from negative control. The lin-ear range of leonurine were 4.05-81.00 μg/mL(r=0.9999). RSDs of precision,stability and reproducibility tests were all lower than 2.0%. The recovery was 98.47%-103.83%(RSD=2.04%,n=9). CONCLUSIONS:Established standard can be used for quali-ty control of Prostatitis capsules.
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<p><b>OBJECTIVE</b>The aim of this study was to investigate the effect of short enamel etching time on bonding strength.</p><p><b>METHODS</b>80 healthy premolars were randomly divided into two equal groups, one was etched for 15 seconds, the other for 60 seconds, after normally bonding Edgewise brackets, the tooth specimen was stored in water at room temperature for 24 hours. An MTS NEW810 100KN testing machine was used to examine the shear force.</p><p><b>RESULTS</b>Although the bonding strength for 15 seconds etching time was weaker than that for 60 seconds, the means of the bonding strength in 15 seconds group reached 5.8625 MPa.</p><p><b>CONCLUSION</b>Etching for 15 seconds could provide enough bond strength for orthodontic practice. Furthermore, the adhesive remained on tooth after debonding was less by comparison with 60 seconds etching group, therefore brackets could be removed easily and the work efficiency could be increased in clinic by means of 15 seconds etching time.</p>